Non-renewable biospecimens available for genomic research (including, but not limited to whole blood, buffy coats, PAXgene blood and, cryopreserved lymphocytes) and the genomic products derived from them (RNA, DNA and amplified products) are important resources for the conduct of current and next generation genomics research. For example, RNA has been extracted from PAXgene tubes and recently used for transcriptional profiling and microRNA profiling (through the NHLBI SABRe Project) as well as quantitative real time-PCR (rtPCR or qPCR) through grant-funded research. An additional use of RNA that may provide a future resource for submission to dbGaP includes genome-wide RNA sequencing. Blood derived DNA has been used for telomere length assays and has been proposed for use in several DNA methylation profiling studies. Additional future uses of blood derived DNA that may provide a future resource include genome-wide (“whole genome”) DNA sequencing.
The FGSC proposes that the following principles be followed when making decisions about non-renewable genomic resources:
Last Updated: Legacy Policy